Neuraminidase



Neuraminidase (NAN) cleave the glycosidic bonds of neuraminic acid. The viral NAN is a drug target for prevention of influenza.

See also Avian Influenza Neuraminidase, Tamiflu and Relenza

3D structures of Neuraminidase
Update June 2011

Neuraminidase
2ya4, 2w20, 2vvz – SpNANA catalytic domain – Streptococcus pneumoniae

3h71 - SpNANA catalytic domain precursor

2vw0, 2vw1, 2vw2 - SpNANB

2xzi, 2xzj, 2xzk, 2xcy – NANA – Aspergillus fumigatus

2w68 – VcNANA sialic acid binding domain – Vibrio cholerae

1w0o, 1kit– VcNANA

1snt, 1so7 – hNeu2 - human

2f24, 2f26, 2f28 – hNeu2 (mutant)

1eur - MvNANA residues 43-407 – Micromonospora viridifaciens

1euu - MvNANA residues 47-647

1wcq, 1w8n, 1w8o, 2hu0, 2hu4 – MvNANA residues 47-647 (mutant)

3sil – StNANA (mutant) – Salmonella typhimurium

Binary complexes of Neuraminidase
3h72 - SpNANA catalytic domain precursor + sialic derivative

3h73 - SpNANA catalytic domain precursor + sialic acid analog

2ya5 - SpNANA catalytic domain + sialic acid

2ya7, 2ya8 - SpNANA catalytic domain + inhibitor

2ya6 - SpNANA catalytic domain + sialic acid analog

2jkb - SpNANB residues 30-697 + sialic acid analog

1w0p – VcNANA + sialic derivative

2f0z, 2f10, 2f11, 2f12, 2f13 – hNeu2 + inhibitor

2f25, 2f27, 2f29 - hNeu2 (mutant) + sialic acid analog

1vcu - hNeu2 + sialic acid analog

1eus - MvNANA residues 43-407 + neuraminic acid derivative

2bzd - MvNANA residues 47-647 (mutant) + galactose

1eut - MvNANA residues 47-647 + galactose

2ber - MvNANA residues 47-647 (mutant) + sialic derivative

1dil, 1dim – StNANA + inhibitor

2sim, 2sil - StNANA + neuraminic acid derivative

Influenza virus neuraminidase
3nss, 3k36, 3beq, 3cye, 2cml, 2b8h, 2ht5, 1v0z, 1nn2 – IvNANA residues 82-469 – Influenza virus

3k38 – IvNANA (mutant)

2ht5 – IvNAN N8 residues 82-469

2htv - IvNAN N4 residues 82-469

2hty - IvNAN N1 residues 82-469

3nn9, 4nn9, 5nn9, 6nn9 - IvNAN N9 residues 82-469

7nn9 - IvNAN N9 Tern

2qwa - IvNAN N9 Tern (mutant)

Binary complexes of Influenza virus neuraminidase
3o9j, 3o9k, 2c4a, 2c4l, 1w1x, 1w20, 1w21, 1nsb, 1nsc, 1nsd – IvNANA + sialic derivative

3k37, 3b7e, 1vcj, 1l7f, 1f8c, 1f8d, 1f8e, 1a4g, 1a4q, 1b9t, 1b9v, 1b9s, 1inf, 1ing, 1inh, 1ivb, 1ivc, 1ivd, 1ive, 1ivf, 1ivg – IvNANA + inhibitor

1f8b, 1inv, 1inw, 1inx, 1iny – IvNANA + sialic acid analog

2ht7, 2ht8, 2htq, 2htu – IvNAN N8 + inhibitor

2htr – IvNAN N8 + sialic acid analog

2htw - IvNAN N4 + sialic acid analog

2bat – IvNAN N2 + sialic acid

1nna, 1nnb - IvNAN N9 + neuraminic acid derivative

1xoe, 1xog - IvNAN N9 Tern + inhibitor

2qwb - IvNAN N9 Tern (mutant) + sialic derivative

2qwc, 2qwd, 2qwe - IvNAN N9 Tern (mutant) + sialic acid analog

1mwe - IvNAN N9 Tern + sialic acid

1bji, 1nnc - IvNAN N9 Tern + sialic acid analog

2qwf, 2qwg, 2qwh, 2qwi, 2qwj, 2qwk - IvNAN N9 Tern (mutant) + inhibitor

1nma, 1nmb - IvNAN N9 Tern + mFAB heavy+light chain – mouse

1a14 - IvNAN + mFAB heavy+light chain

1nca, 1ncb, 1ncc, 1ncd - IvNAN N9 + mFAB heavy+light chain

3k39, 3k3a, 3ckz, 3cl0, 3cl2, 1l7g, 1l7h - IvNANA (mutant) + inhibitor

2aep, 2aeq – IvNANA + mFAB heavy+light chain

Endo-neuraminidase
3gvf, 3gvk, 3gvj – ENANA (mutant) residues 246-910 – Enterobacteria phage K1F

3gvl, 3ju4 – ENANA residues 246-910

3gw6 – ENANA residues 790-1064

Pseudaminidase
2w38 – PNANA – Pseudomonas aeruginosa

Trans-sialidase
2sli, 1sli, 3sli – lTS + inhibitor – leech